ERα promotes murine hematopoietic regeneration through the Ire 1 α - mediated unfolded 3 protein response 4 5 Richard
نویسندگان
چکیده
Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, 9 USA 10 Graduate Program in Translational Biology and Molecular Medicine, Baylor College of 11 Medicine, Houston, TX 77030, USA 12 Division of Hematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, 13 MI 48109, USA 14 Division of Cell Medicine, Department of Life Science, Medical Research Institute, Kanazawa 15 Medical University, Kahoku, Ishikawa 920-0293, Japan 16 17 18 Correspondence to [email protected] 19
منابع مشابه
ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response
Activation of the unfolded protein response (UPR) sustains protein homeostasis (proteostasis) and plays a fundamental role in tissue maintenance and longevity of organisms. Long-range control of UPR activation has been demonstrated in invertebrates, but such mechanisms in mammals remain elusive. Here, we show that the female sex hormone estrogen regulates the UPR in hematopoietic stem cells (HS...
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